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Global Experts Meeting on Infectious Diseases

Tokyo, Japan

Maduike C. O. Ezeibe,

Maduike C. O. Ezeibe,

Michael Okpara University of Agriculture,Nigeria

Title: Antiviral mechanisms of the Medicinal synthetic Aluminum-magnesium silicate {Al4 (SiO4)3 + 3Mg2SiO4 → 2Al2 Mg3 (SiO4)3}, against immune deficiency (“incurable”) infections (HIV, HBV and HCV)


Biography: Maduike C. O. Ezeibe,


Small sizes of viruses enable them infect cells that are inaccessible to medicines of large molecules. So, termination of viral infections requires synergy between immunity and medicines. The Human immune deficiency virus (HIV) depletes lymphocytes (general immunity). Hepatitis B virus (HBV) and Hepatitis C virus (HCV) impair the liver (innate and adaptive immunity). Since lymphocytes are not life-sustaining HIV-infections do not cause immediate death. So, its infections are chronic. The liver regenerates.  So, HBV and HCV-infections are also chronic. Their chronic nature makes the diseases require prolonged treatment before cure. Prolonged medication with antiviral medicines of biochemical-effects causes toxicity (because of similarity between viral biochemistry and human-cells` biochemistry). Medicines of physical-effects (mopping/binding) need to reach every infected cell before they can terminate infections. Under state of immune deficiency, physical-effect medicines which do not reach all infected cells cannot terminate viral infections.  Those infected cells which are inaccessible to medicines are the cells called “sanctuary-cells” or “infections-reservoirs”. Molecules of Aluminum-magnesium silicate (AMS) are made of Nanoparticles that are only 0.96nm thick (< HIV, HBV, HCV). So, they reach all infected cells.  Edges of the Nanoparticles are positively charged and their surfaces, negatively charged. HIV and HCV are positively charged while HBV is negatively charged. So, AMS-Nanoparticles bind to HIV and HCV with their surfaces and to HBV with their edges. They bind to and destroy infected cells with their edges because abnormal (infected and cancer) cells are negatively charged .The “sanctuary cells” (infected cells) are also destroyed. So, “hidden infections” are unmasked. When all particles of a virus infecting   a patient`s organs/tissues are mopped out, he or she is cured. Also, silicates are immune stimulants. Added to these, AMS stabilizes antimicrobials. Stabilizing medicines prolongs their bioavailability. Prolonging bioavailability improves efficacy of medicines. With improved efficacy, lower doses of antimicrobials achieve desired effects and use of lower doses for treatments minimizes side effects of medicines. Minimizing side effects of medicines adds to enhancement of patients` immune responses. Synergy between Antiviral effects of AMS, improvement in efficacies of antimicrobials and enhanced immune responses lead to effective treatment of both the viral infections and secondary infections. Nigeria does not have AMS {AlMg3(SiO4)3}  but  there are  large deposits  of Aluminum silicate {Al4(SiO4)3} and Magnesium silicate  (Mg2SiO4) in the country . Therefore, Aluminum silicate and Magnesium silicate were reacted to get the Medicinal synthetic Aluminum-magnesium silicate {MSAMS: Al(SiO4)3 + 3Mg2SiO4 → 2AlMg(SiO4)3}.