Global Experts Meeting on Infectious Diseases
Walailak University, Thailand
Title: In Vivo Antimalarial Activity of Crude Extracts from Medicinal Plants
Biography: Voravuth Somsak
Malaria is still one of the most deadly parasitic disease, having a high rate of incidence and mortality across the world. The spread and development of resistance against chemical insecticides is one of the major problems associated with malaria treatment and control. Hence, plant based formulations may serve as an alternative source towards development of new drugs for treatment of malaria. The present study was aimed to validate the medicinal plant extracts against Plasmodium berghei infected mice as in vivo model. Crude extracts of the selected plants were prepared and tested for acute toxicity. The antimalarial including prophylacitc, chemosuppressive, and curative activities of these extracts were evaluated. When oral administered, no adverse and toxic effects were noted for these plant extracts ranging from 1,000-2,000 mg/kg doses signifying the safety in mice via oral route. Moreover, good chemosuppressive, moderate prophylacitc and curative activities against P. berghei infected mice of these extracts were observed. Additionally, protection body weight loss, hematological abnormalities, and prolonged mice mean survival time were also considered. The finding supports the traditional use of the plants for the treatment of malaria, and could serve as the potential source of new and novel antimalarial leads for the treatment and prevention of malaria.