Samer M. Al-Hulu
Al-Qasim Green University, Iraq
Title: Some Notes about Medical applications for Microbial Biosurfactants
Submitted Date: 2019-02-10
Biography
Samer M, Al-Hulu, Microbiology Specialist, has completed his PhD from Babylon University/College of Science. He has published more than 14 papers in microbiology field. Al-Hulu, has training at Ministry of Health at Laboratory of Babylon Maternity and Children Hospital. Now working at Al-Qasim Green University/College of Environmental Sciences .
Abstract
Biosurfactants are amphiphilic biological compounds created extracellular or cell membrane part by bacteria, yeast ,and filamentous fungi. Biosurfactants are made up of a hydrophilic moiety, may be acid, peptide, cation, anion, mono, di, or polysachharides; and a hydrophobic moiety, which may be unsaturated, or saturated hydrocarbon chains, or fatty acids. Many advantages for biosurfactants includes: Biodegradability, low toxicity, Biocompatibility and digestivity , availability of raw materials and specificity. The biosurfuctant production was detected by many method includes ,Hemolytic activity, Oil displacement test Emulsification index , Surface tension reduction ,Blue agar plate or CTAB agar plate Method ,Hydrocarbon overlay agar Method. There are many Medial application for Biosurfactant includes , Antimicrobial activity: Biosurfactants having ability to be toxic on cell membrane permeability in similar method to detergent effect, Anti-cancer activity, the Neuronal differentiation in PC 12 cells induced by MEL and get ready the ground work for the use of microbial extracellular glycolipids as novel reagents for cancer cell treatment, Antiviral activity, The Sophorolipids surfactants produce by C. bombicola having structural analogues such as the sophorolipid diacetate ethyl ester which is powerful spermicidal and virucidal agent, and its virucidal activity similar to nonoxynol – 9 against the human semen. Anti-adhesive agents, Biosurfactants having ability for adhesion inhibiting for pathogenic organisms to solid surfaces or infection site, Anti-Fungal Activity, Flocculosin is a glycolipid produced by yeast like fungus P. flocculosa having antifungal activity against pathogenic yeasts and human mycoses. Immunological adjuvants, Bacterial lipopeptides when mix with classic antigens having active nontoxic, non pyrogenic immunological adjuvants. Gene delivery, The liposomes based on biosurfactants having increasing efficiency for gene transfection than cationic liposomes trading use.