Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

Global Experts Meeting on Infectious Diseases

Tokyo, Japan

Xavier Fernàndez Busquets

Xavier Fernàndez Busquets

The Barcelona Institute of Science and Technology
Spain

Title: Turning against Plasmodium its own Survival Strategies

Biography

Biography: Xavier Fernàndez Busquets

Abstract

The fragile malaria parasite, Plasmodium spp., through millions of years of coevolution with its natural hosts, has developed exquisitely sophisticated strategies to survive hostile environments in the blood and in mosquito tissues. Some of its tricks are, among others, (i) using as human host cell erythrocytes, which do not emit any alarm signal when they are parasitized by the pathogen; (ii) adhering to vascular endothelia to remove itself from the circulation thus avoiding spleen clearance; and (iii) escaping to a different host (the insect) when threatened in the human. We will discuss how we might profit from these evolutionary adaptations and turn them against the parasite, e.g. by (i) harnessing erythrocytes as antimalarial drug carriers, (ii) employing as targeting elements of drug-loaded nanovectors certain cell surface ligands used by Plasmodium for its sequestration in capillaries, or (iii) drugging parasite stages in the mosquito vector and thus avoiding lengthy and expensive clinical assays.