Tian-Hua Huang
Shantou University Medical College,China
Biography
Professor Tianhua Huang has been engaged in vertical transmission of hepatitis B virus (HBV) via germline and its mechanism for more than 20 years and demonstrated that (1) HBV DNA can integrate into patients’ sperm genome and induce sperm chromosomal abnormalities; (2) spermatozoa carrying HBV genes can achieve normal fertilization; (3) the sperm-introduced HBV genes retained their competency of replication, transcription and translation in embryos; (4) HBV surface protein can trigger caspase-dependent and caspase-independent apoptosis resulting in sperm dysfunction and decreased sperm fertilizing capacity; (5) HBV gene expression is regulated by CpG methylation, host genes and microRNAs in patients’ spermatozoa and sperm-derived embryos.
He has published more than 200 research articles. For his distinguished achievement, he received 4 academic awards issued by the National Health and Family Planning Commission and Provincial Government, China. In 2006 he won the second place of the 7th ROYAN International Research Award in Tehran Iran.