Infectious Diseases

Infection and cancer:

Most human tumors, 20% of them, are assumed to be caused by infections. This explains why the contribution of bacteria to the development of cancer has been largely underappreciated. Although epidemiological evidence ties some malignancies to bacterial infections, the genesis of tumours is typically believed to be entirely a result of the inflammatory reactions that ensue. Many bacteria do, however, directly impact their host cell at various times during the infection cycle. A host cell's integrity may be compromised by such modifications, which can also aid in the growth of cancer. In this study, we demonstrate how bacteria's surface components, protein toxins, and effector proteins may damage DNA in host cells while interfering with crucial host cell signalling pathways, such as cell division, proliferation, apoptosis, and immunological signaling. Hepatocellular carcinoma and hepatitis B and C infections are linked.